Carboplatin (Calvert) dose
Carboplatin is dosed to a target AUC, not by body-surface area — so renal function is built directly into the prescription via the Calvert formula. Enter the patient's details for an estimated Cockcroft-Gault creatinine clearance and the resulting total dose, with the GFR cap that prevents overdosing when creatinine-based GFR runs high.
Enter age, weight, creatinine (or a measured GFR) and a target AUC to compute the dose.
How it works
The Calvert formula sets the total carboplatin dose (mg) = target AUC × (GFR + 25), where GFR is in mL/min. Because the dose scales directly with GFR, an accurate renal-function estimate is the single most important safety step: a falsely high GFR overdoses, a falsely low one underdoses. When creatinine is measured with modern IDMS-standardized assays — or in patients with low muscle mass — estimated GFR can be spuriously high, so capping the GFR estimate at 125 mL/min is the widely recommended guard against overdose.
The creatinine clearance here uses Cockcroft-Gault: CrCl = [(140 − age) × weight(kg) × (0.85 if female)] / (72 × serum creatinine in mg/dL). Prefer a measured or isotopic GFR when one is available (enter it in the override field).
Reference: Calvert AH et al. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol 1989;7(11):1748–56 — PMID 2681557. See also the carboplatin profile and the eGFR dosing assistant.
Medical-education content only — not medical advice. Confirm all dosing against current product labeling, institutional protocols, and pharmacy review.