Machine-readable NephTox
A versioned, read-only JSON projection of the whole citation-grounded catalog — 263 agents, their injury signatures, nephron targets, evidence bounds, phenotype neighbors, and aggregate FAERS reporting signals. Built for researchers, EMR/formulary tools, and other apps.
Endpoints
Base path /api/v1 · responses carry a schemaVersion (1.0.0).
The full agent index — id, name, class + family, signature injury, nephron segment, severity, era, approval year, and whether the agent carries a FAERS AKI reporting signal.
One agent in full: ranked injuries, nephron segments, citation-year bounds, aggregate FAERS AKI reporting odds ratio (point estimate + 95% CI + report count), and its top phenotype-nearest agents.
The 14-lesion kidney-injury taxonomy and the nephron-segment vocabulary the catalog is coded against.
Example response
GET /api/v1/drugs/cisplatin
{
"schemaVersion": "1.0.0",
"drug": {
"id": "cisplatin",
"name": "Cisplatin",
"class": "Platinum agent",
"classFamily": "Platinum agents",
"signatureInjury": "atn",
"nephronSegment": "proximal",
"severity": "severe",
"era": null,
"yearApproved": 1978,
"faersAkiSignal": true,
"injuries": [{ "injury": "atn", "tier": "primary" }, ...],
"nephronSegments": ["proximal", "distal", "vasculature"],
"evidence": { "citations": 14, "firstYear": 1999, "newestYear": 2025 },
"faersAki": { "ror": 3.35, "ci95": [3.195, 3.51], "reports": 1804 },
"phenotypeNeighbors": [{ "id": "arsenic-trioxide", "similarity": 0.758 }, ...],
"links": { "profile": "/drugs/cisplatin", "api": "/api/v1/drugs/cisplatin" }
}
}Terms
Aggregate data only — the API never exposes per-report FAERS term tables, and FAERS reporting odds ratios reflect disproportionate reporting, not incidence or proven causation. All values derive from the same citation-grounded seed as the site; see Methods & Provenance. Educational use; not medical advice. Please attribute NephTox and cite the underlying primary sources, not the API, in scholarly work.