The dosing reference
Creatinine-clearance thresholds and dialyzability for 288 agents: does the dose change in renal impairment, and is the drug removed by dialysis? Switch to Needs a renal change for the 65 agents that require a specific adjustment, or Dialysis to filter by hemodialysis removal, peritoneal-dialysis and CRRT guidance, dose-adjustment, and the 28 agents contraindicated in dialysis. Or work a single patient with the Dosing Assistant (enter an eGFR) and the Carboplatin Calculator. Every row links to its profile.
Enter age, weight, creatinine (or a measured GFR) and a target AUC to compute the dose.
How it works
The Calvert formula sets the total carboplatin dose (mg) = target AUC × (GFR + 25), where GFR is in mL/min. Because the dose scales directly with GFR, an accurate renal-function estimate is the single most important safety step: a falsely high GFR overdoses, a falsely low one underdoses. When creatinine is measured with modern IDMS-standardized assays — or in patients with low muscle mass — estimated GFR can be spuriously high, so capping the GFR estimate at 125 mL/min is the widely recommended guard against overdose.
The creatinine clearance here uses Cockcroft-Gault: CrCl = [(140 − age) × weight(kg) × (0.85 if female)] / (72 × serum creatinine in mg/dL). Prefer a measured or isotopic GFR when one is available (enter it in the override field).
Reference: Calvert AH et al. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol 1989;7(11):1748–56 — PMID 2681557. See also the carboplatin profile and the .
A teaching reference, not a dosing calculator— always confirm against the current prescribing information and your institutional protocol before adjusting therapy. Thresholds are summarized from each agent’s profile and its cited sources; the grouped rules are concise paraphrases verified against FDA labels. Medical-education content only — not medical advice.