Abiraterone
Zytiga · CYP17 inhibitor
Mineralocorticoid excess: hypokalemia, hypertension, edema.
LYTEHTN
ModerateOpen →
The Drug Explorer
Search the nephrotoxic landscape
A live index of 240+ anti-cancer agents, cross-filterable by injury signature, drug class, nephron segment, severity, and era. Profiled agents open to a full citation-grounded page; the rest are catalog entries with their signature kidney signal.
27 agents · filtered from 240
Profile
Acalabrutinib
Calquence · BTK inhibitor
Tumor lysis; lower hypertension than ibrutinib.
HTNPRE
MildOpen →
Asciminib
Scemblix · BCR-ABL STAMP inhibitor
Hypertension and pancreatitis; allosteric BCR-ABL inhibitor.
HTNLYTE
MildOpen →
Bevacizumab
Avastin · Anti-VEGF antibody
Proteinuria, hypertension, glomerular TMA.
GLOMHTNTMA
ModerateOpen →
Cabozantinib
Cabometyx · VEGFR/MET TKI
Hypertension and proteinuria; nephrotic case reports.
HTNGLOM
ModerateOpen →
Carfilzomib
Kyprolis · Proteasome inhibitor
AKI, TMA and hypertension — a hot myeloma signal.
TMAATNHTN
SevereOpen →
Copanlisib
Aliqopa · Pan-PI3K inhibitor
Transient infusion-related hypertension and hyperglycemia.
HTNLYTE
ModerateOpen →
Dinutuximab
Unituxin · Anti-GD2 antibody
Capillary-leak syndrome, hypertension and severe pain in neuroblastoma.
PREHTN
ModerateOpen →
Enzalutamide
Xtandi · Androgen-receptor inhibitor
Hypertension; rare electrolyte effects.
HTNLYTE
MildOpen →
Fruquintinib
Fruzaqla · VEGFR TKI
2023 colorectal VEGFR-TKI; hypertension and proteinuria, class effect.
HTNGLOM
ModerateOpen →
Gemcitabine
Gemzar · Nucleoside analog
Dose-cumulative thrombotic microangiopathy.
TMAHTNGLOM
SevereOpen →
Ibrutinib
Imbruvica · BTK inhibitor
Tumor lysis, hypertension and AKI.
HTNPREGLOM
ModerateOpen →
Lenvatinib
Lenvima · VEGFR TKI
Highest-ranked TKI for hypertension; proteinuria.
HTNGLOM
ModerateOpen →
Leuprolide
Lupron · GnRH agonist
Metabolic syndrome; indirect renal risk.
HTNLYTE
MildOpen →
Nilotinib
Tasigna · BCR-ABL TKI
eGFR decline over time.
PREHTNPSEUDO
MildOpen →
Nintedanib
Ofev · VEGFR/FGFR/PDGFR TKI
Proteinuria and rare TMA.
HTNTMAGLOM
MildOpen →
Niraparib
Zejula · PARP inhibitor
Hypertension and creatinine rise.
HTNPRE
MildOpen →
Ponatinib
Iclusig · BCR-ABL TKI
Vascular toxicity and hypertension.
HTNPRE
ModerateOpen →
Pralsetinib
Gavreto · RET inhibitor
Hypertension; rare AKI.
HTNPRE
MildOpen →
Ramucirumab
Cyramza · Anti-VEGFR2 antibody
Hypertension and proteinuria, class effect.
HTNGLOMTMA
ModerateOpen →
Regorafenib
Stivarga · VEGFR TKI
Hypertension and proteinuria.
HTNGLOM
ModerateOpen →
Ripretinib
Qinlock · KIT switch-control inhibitor
Hypertension and alopecia in GIST.
HTN
MildOpen →
Selpercatinib
Retevmo · RET inhibitor
Hypertension and creatinine rise.
HTNPRE
ModerateOpen →
Tivozanib
Fotivda · VEGFR TKI
Hypertension and proteinuria in RCC.
HTNGLOM
ModerateOpen →
Vandetanib
Caprelsa · VEGFR/EGFR/RET TKI
Hypertension; QT prolongation.
HTNGLOM
ModerateOpen →
VEGFR TKIs (sunitinib · sorafenib · pazopanib · axitinib)
VEGFR TKI
Hypertension as an on-target marker; proteinuria.
HTNGLOMTMA
ModerateOpen →
Ziv-aflibercept
Zaltrap · VEGF trap
Hypertension and proteinuria like bevacizumab.
HTNGLOMTMA
ModerateOpen →