Skip to content
Multiple myeloma diagnosed after contrast-enhanced computed tomography without renal complications: a case report with literature review

Start here

Choose a path through the atlas

NephTox is a large reference — 288 agents, 14 injury signatures, and 1,473 citations. Rather than wander, pick the journey that matches why you came: each path is a short, ordered walk through the pages that answer it, with a line on why each step comes next.

Prefer to browse freely? Open the explorer or the master atlas.

At the Bedside

An oncologist or nephrologist with a patient whose creatinine is climbing on active therapy

From an unexplained creatinine bump to a named culprit and a concrete plan.

  1. Bedside Culprit ConsoleEnter the active meds, timeline, and urine findings and get a ranked shortlist of the likely offenders.
  2. Cisplatin deep profileOpen the top suspect and confirm the phenotype fits: signature injury, onset window, and FAERS AKI signal.
  3. Acute tubular necrosis hubPressure-test the lesion you're betting on and how it separates from AIN or prerenal, so you don't anchor on the first suspect.
  4. Renal dosing referenceDecide the next move for that agent: hold, dose-adjust to CrCl, or continue.
  5. Managing established toxicityClose with the bedside plan: hydration, electrolyte repletion, and when to stop or rechallenge.

Learn the Field

A trainee or clinician new to onco-nephrology building the fundamentals

Build onco-nephrology from vocabulary to pattern to a worked syndrome, then test it.

  1. The lesion atlasStart with the vocabulary: the 14 kidney-injury signatures the whole field runs on.
  2. Interactive nephronPlace each signature in space and see which tubular segment the damage lands on.
  3. Class × Injury matrixZoom out to the patterns: which drug classes drive which injuries.
  4. Cisplatin ATN & hypomagnesemiaWatch one classic syndrome unfold end-to-end, from mechanism to bedside management.
  5. Self-assessmentTest what stuck before you take it to the wards.

Follow the Evidence

A researcher or evidence-minded reader who trusts nothing unsourced

Survey the field from altitude, then trace every claim to its source and the people behind it.

  1. The data-viz hubSee the field at altitude: the similarity map, FAERS volcano, and effect-size forests across all 288 agents.
  2. Landmark evidence galleryMeet the seminal trials and the headline numbers they produced.
  3. Citations & society guidelinesTrace any claim to its PubMed record and the guideline (KDIGO, ASCO, ESMO) that acts on it.
  4. Contributor bibliometricsSee who actually drives each subfield of onco-nephrology, and whom to read next.

The Classic Nephrotoxins

Anyone who wants the classic offenders cold, the drugs to recognize on sight

The nephrotoxins every onco-nephrologist must know, each a different lesion.

  1. CisplatinThe prototype: dose-dependent proximal-tubule ATN and magnesium wasting.
  2. High-dose methotrexateThe crystal-nephropathy classic, and why urine pH and glucarpidase matter.
  3. IfosfamideFanconi syndrome and proximal tubulopathy, the teaching case for tubular dysfunction.
  4. BevacizumabThe VEGF story: proteinuria, hypertension, and glomerular injury from a targeted agent.
  5. PembrolizumabThe modern classic: checkpoint-inhibitor interstitial nephritis you can't miss.
  6. Toxic-ties graphStep back and watch these offenders cluster by the injury signatures they share.

Dose It Right

A pharmacist or prescriber getting renal dosing right across a regimen

Screen the protocol for kidney risk, then set and compute the right dose.

  1. Regimen kidney-risk checkEnter the full protocol and read the combined renal risk, and which single agent is driving it.
  2. Methotrexate deep profileWork the clearance-critical exemplar: leucovorin rescue, alkalinization, and glucarpidase thresholds.
  3. Renal dosing referenceFor whatever you keep, find which agents need a change and the exact CrCl-appropriate rule.
  4. Calvert / carboplatin calculatorRun the AUC math to land the concrete carboplatin dose you'll actually prescribe.