Chlorambucil
Leukeran · Alkylating agent (nitrogen mustard)
Minimal direct nephrotoxicity; rare drug-associated SIADH/hyponatremia is the kidney-relevant signal.
SIADHLYTE
MildOpen →
The Drug Explorer
Search the nephrotoxic landscape
A live index of 240+ anti-cancer agents, cross-filterable by injury signature, drug class, nephron segment, severity, and era. Profiled agents open to a full citation-grounded page; the rest are catalog entries with their signature kidney signal.
16 agents · filtered from 240
Profile
Cyclophosphamide
Cytoxan · Oxazaphosphorine alkylator
Vasopressin-independent hyponatremia; hemorrhagic cystitis.
SIADHCYST
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Lazertinib
Lazcluze · EGFR TKI (3rd-gen)
2024 EGFR TKI; hyponatremia like osimertinib.
SIADHLYTE
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Melphalan
Alkeran · Alkylator
SIADH in high-dose myeloma conditioning; renally cleared.
SIADHLYTE
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Mitotane
Lysodren · Adrenolytic
Indirect: hypoadrenalism drives hyponatremia/prerenal; cisplatin nephrotoxicity in EDP-M.
LYTEPRESIADH
ModerateOpen →
Octreotide
Sandostatin · Somatostatin analog
Kidney-neutral/possibly renoprotective; renally cleared, caution in severe CKD/dialysis.
LYTEPRESIADH
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Osimertinib
Tagrisso · EGFR TKI
Hyponatremia and occasional AKI.
SIADHLYTE
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Selinexor
Xpovio · XPO1 (nuclear export) inhibitor
Hyponatremia is common and dose-limiting.
SIADHLYTEPRE
ModerateOpen →
Sunvozertinib
Zegfrovy · EGFR exon20 TKI
2025 EGFR exon20 TKI; electrolyte effects emerging.
SIADHLYTEPRE
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Tamoxifen
Nolvadex · SERM
Hypercalcemia flare; rare hyponatremia.
SIADHLYTE
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Temozolomide
Temodar · Alkylator
Occasional SIADH; generally renally well tolerated.
SIADHLYTE
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Vinblastine
Velban · Vinca alkaloid
SIADH and rare Raynaud/vascular events.
SIADHLYTE
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Vincristine
Oncovin · Vinca alkaloid
SIADH → hyponatremia.
SIADHLYTE
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Vinflunine
Javlor · Vinca alkaloid
Used because of renal impairment (cisplatin-unfit urothelial); CrCl-based dose bands; watch SIADH/hyponatremia.
LYTEPRESIADH
MildOpen →
Vinorelbine
Navelbine · Vinca alkaloid
SIADH reports.
SIADHLYTE
MildOpen →
Vismodegib
Erivedge · Hedgehog (SMO) inhibitor
Muscle spasms; hyponatremia reported.
SIADHLYTE
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