RCYST

Renal Cysts

Drug-induced complex renal cysts — the distinctive ALK-inhibitor lesion, classically crizotinib. Usually asymptomatic, dose/duration-related, and they tend to regress when the drug is stopped.

1agents

Where it strikes

Distal Tubule / Collecting Duct

Fine-tuning of Na, K, Mg, acid & water

See it on the nephron

Severity mix

Mild· 1

Reversibility

Reversible· 1

Signature offenders

Agents for which renal cysts is the defining renal lesion.

CrizotinibCreatinine rise often within weeks and reverses on discontinuation; cysts develop and grow over months.Crizotinib commonly causes a reversible rise in serum creatinine and is distinctively associated with the development and progression of complex renal cysts. Peripheral edema and electrolyte disturbances (including hypophosphatemia and hypokalemia) are reported. In real-world ALK-inhibitor cohorts, creatinine-based AKI/CKD events are frequent but mostly mild and reversible; frank kidney failure is uncommon.Mild

See these on the Toxic-Ties graph All 14 lesions